New Approaches to INOCA

Pasquale Mone

Status: Completed

Conditions: New Approaches in INOCA

Treatments: Drug: Metformin

Study type: Observational

Funder types: Other

Identifiers

NCT05740345

Campania Nord 2

Details and patient eligibility

About

Ischemia with non-obstructive coronary arteries (INOCA) is common in patients with angina. INOCA has been associated with an increased risk of death, myocardial infarction, and stroke, particularly in symptomatic subjects. Previous investigations have evidenced the key role of poor glycemic control and diabetes in coronary microvascular dysfunction. Metformin is an old oral antidiabetic drug which is currently used to achieve glycemic control.

Full description

Ischemia with non-obstructive coronary arteries (INOCA) is common in patients with angina. INOCA has been associated with an increased risk of death, myocardial infarction, and stroke, particularly in symptomatic subjects. Coronary microvascular dysfunction, triggering structural remodeling and vasomotor disorders of coronary arterioles, is currently one of the leading hypotheses to explain INOCA pathophysiology. Previous investigations have evidenced the key role of poor glycemic control and diabetes in coronary microvascular dysfunction. Metformin is an old oral antidiabetic drug which is currently used to achieve glycemic control. Also, previous reports evidenced that metformin improves endothelial dysfunction. Nowadays, it is used in prediabetic patients too. In this scenario, we evaluated the role of metformin in reducing the risk of re-hospitalization in INOCA.

Enrollment: 3,000 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age ≥18 years;
• diagnosis of INOCA;
• availability to participate in the study

Exclusion criteria

• cancer;
• atrial fibrillation or left bundle branch block;
• previous acute coronary syndrome (ACS) or cardiac revascularization; -pregnancy;
• severe heart valve disease

Trial design

3,000 participants in 2 patient groups

Hyperglycemia/Normoglycemia

Treated/No treated

Treatment:

Drug: Metformin