New Automated System for Continuous Real-time Monitoring of Transpulmonary Pressure

University of Milan

Status: Unknown

Conditions: Ventilator-Induced Lung Injury; Acute Respiratory Failure

Treatments: Device: OPTIVENT

Study type: Observational

Funder types: Other

Identifiers

NCT03945409

INNOVENT-2019

Details and patient eligibility

About

Patients admitted to Intensive Care Unit often are affected by acute respiratory failure at admission or during hospital stay, with a mortality of 30%.

Treatment remains largely supportive with mechanical ventilation as the mainstay of management by improving the hypoxemia and reducing the work of breathing; however, the mechanical forces generated during ventilation can further enhance pulmonary inflammation and edema, a process that has been termed ventilator induced lung injury (VILI). Consequently, in clinical practice the lung protective ventilation is mainly based on the reduction of the tidal volume, the airway and the transpulmonary plateau pressure. A good clinical practice is based on the assessment of changes in respiratory mechanics.

Aim of the study is to determine the accuracy of the OPTIVENT system in measuring transpulmonary pressure, comparing it with the systems currently in use in our Operative Unit.

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• acute respiratory failure
• invasive mechanical ventilation.

Exclusion criteria

• haemodynamic instability
• presence of barotrauma
• esophageal disease.