New Biomarkers in Axial Sypondyloarthropathy; SII and SIRI

Istanbul Training and Research Hospital

Status: Completed

Conditions: Axial Spondyloarthritis

Treatments: Other: lab testing

Study type: Observational

Funder types: Other

Identifiers

NCT05914532

19/08/2022, 2011-KAEK-50: 262

Details and patient eligibility

About

investigators aimed to evaluate the relationship between Systemic Immune Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) and disease activity in patients with axial spondyloarthropathy (SpA).

Full description

The clinical characteristics and laboratory data of the patients and healthy controls participating in our study were obtained through the hospital system. Then, the new biomarkers SIRI and SII values were calculated. SIRI= neutrophil count*monocyte count/lymphocyte count and SII= neutrophil count*platelet count/lymphocyte count. Then, SIRI and SII values were compared between groups. The relationship between disease activity and SIRI and SII values in the patient group was examined.

Enrollment: 155 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• SpA patients diagnosed according to the 2009 Assessment of Spondyloarthritis International Society classification criteria
• 51 healthy controls working in our hospital,

Exclusion criteria

infections, coronary artery disease, kidney and liver dysfunction, cancer diagnosis, surgery in the last three months, diabetes mellitus diagnosis, hypertension and pregnant women

Trial design

155 participants in 2 patient groups

group 1

Description:

healthy controls

Treatment:

Other: lab testing

group 2

Description:

axial spondyloarthropathy

Treatment:

Other: lab testing