New Biomarkers in the Intracystic Liquid of Inflammatory and Non-inflammatory Pancreatic Cysts

Iuliu Hatieganu University of Medicine and Pharmacy

Status: Completed

Conditions: Pancreatic Cyst

Treatments: Diagnostic Test: Endoscopic ultrasound fine needle aspiration (EUS-FNA)

Study type: Observational

Funder types: Other

Identifiers

NCT05568433

202042018

Details and patient eligibility

About

Due to the advances made in the field of the imaging techniques and their common use, pancreatic cysts are more and more incidentally found.

Pancreatic pseudocysts can be misdiagnosed as cystic neoplasms, in particular when there is no clinical history of acute or chronic pancreatitis. Pancreatic cystic neoplasms on the other hand are rare, but are difficult to diagnose accurately.

Neutrophil gelatinase-associated lipocalin (NGAL) , interleukin 1 Beta (IL1beta) and High Mobility Group AT-Hook 2 (HmgA2) are molecules implicated in the process of inflammation and tumour development. The diagnostic value of their concentration in pancreatic cysts is not established yet.

Study aim to asses the significance of NGAL,IL1Beta and HMGA2 concentration in cystic fluid obtained by endoscopic ultrasound (EUS) with EUS-guided fine-needle aspiration (EUS-FNA) and serum level for discriminating between inflammatory and non-inflammatory pancreatic cyst.

Enrollment: 63 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients aged 18-90 years with an unclear specific diagnosis of pancreatic cysts
• pancreatic cyst >15mm on CT or MRI
• patients with pseudocysts with indication for drainage

Exclusion criteria

• refusal to participate
• platelet level < 50000/mm3 and International normalized ratio (INR >1.5)
• duodenal stenosis
• severe chronic pancreatitis
• history of pancreatic cancer or major upper abdominal surgery
• congestive heart failure
• the liquid sample < 1ml;