New Biomarkers in the Prediction of Chemotherapy-induced Cardiotoxicity.

Cardiology Prague

Status: Enrolling

Conditions: Cardiotoxicity; Chemotherapy Effect; Chemotherapy Induced Systolic Dysfunction

Treatments: Diagnostic Test: 24-hours monitoring of ECG; Diagnostic Test: Echocardiography; Diagnostic Test: 24 hours monitoring of BP; Diagnostic Test: Blood sampling; Diagnostic Test: Cardio MRI

Study type: Observational

Funder types: NETWORK; Other

Identifiers

NCT05992337

Version_Protocol_3_5_2021

Details and patient eligibility

About

Early detection and thus rapid therapy of cardiotoxicity related to chemotherapy are essential for restoring cardiovascular function. The complete recovery of the cardiovascular system decreases with time to identify the presence of cardiotoxic damage. The project aims to define new biomarkers for the early detection of cardiotoxicity in patients treated with chemotherapy.

Full description

The most effective approach to minimizing the consequences of cardiotoxicity of oncological treatment is its early identification, adjustment of oncological treatment (change of procedure, dose, drugs), and immediate initiation of cardiovascular therapy. However, the current standard for monitoring the cardiovascular system in cancer patients identifies cardiotoxicity only if functional impairment has already occurred, which precludes any chance of effective prevention. The aim of the project is to identify new biomarkers for the early detection of the cardiotoxic effect of chemotherapy in women with breast cancer.

Enrollment: 200 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Breast cancer
• Chemotherapy with a known cardiotoxic side effect

Exclusion criteria

• Known cardiovascular disease

Trial design

200 participants in 2 patient groups

Women with breast cancer treated with chemotherapeutics without signs of cardiotoxicity

Treatment:

Diagnostic Test: Blood sampling

Diagnostic Test: Echocardiography

Diagnostic Test: 24-hours monitoring of ECG

Women with breast cancer treated with chemotherapeutics with signs of cardiotoxicity

Treatment:

Diagnostic Test: Blood sampling

Diagnostic Test: Echocardiography

Diagnostic Test: Cardio MRI

Diagnostic Test: 24 hours monitoring of BP

Diagnostic Test: 24-hours monitoring of ECG