New Echocardiographic Parameters for Assessment of Longitudinal Left Ventricular Function (LAX)

Heidelberg University

Status: Completed

Conditions: Cardiovascular Pathology

Study type: Observational

Funder types: Other

Identifiers

NCT01275963

S-401/2010

Details and patient eligibility

About

Assessment of left ventricular systolic function is the most frequent indication for routine echocardiography. Qualitative eyeball method and biplane modified Simpson's rule, both measuring radial ventricular function, are the currently recommended methods to meet this challenge. Due to the complexity of the myocardial architecture, global left ventricular function also has longitudinal and torsional components.

The aim of this study is to evaluate new echocardiographic parameters for longitudinal left ventricular function. A special focus is set on strain imaging by speckle tracking, which is a relatively new technique. Patients with different cardiac pathologies (e. g. dilated cardiomyopathy, coronary artery disease, diastolic dysfunction) will be included and compared to healthy individuals.

Enrollment: 400 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• persons of 18 years and older who receive a transthoracic echocardiography at our department
• written consent

Exclusion criteria

• permanent pacemaker rhythm
• moderate/severe valvular heart disease

Trial design

400 participants in 8 patient groups

Control

Description:

Healthy individuals without structural heart disease

CAD

Description:

Patients with coronary artery disease

DCM

Description:

Participants with dilated cardiomyopathy

HNCM

Description:

Patients with hypertrophic non-obstructive cardiomyopathy

HOCM

Description:

Patients with hypertrophic obstructive cardiomyopathy

RCM

Description:

Patients with restrictive cardiomyopathy

Amyloidosis

Description:

Patients with cardiac manifestation of amyloidosis

HFPEF

Description:

Patients with heart failure with preserved ejection fraction (diastolic heart failure)