New Method Using Deuterium Labelled Creatine to Measure Total Body Skeletal Muscle Mass

GlaxoSmithKline (GSK)

Status: Completed

Conditions: Sports Nutritional Sciences

Treatments: Dietary Supplement: D3 Creatine; Dietary Supplement: Creatine

Study type: Interventional

Funder types: Industry

Identifiers

NCT02519751

202600

Details and patient eligibility

About

Creatine (methyl-d3) dilution (D3-creatine) is a novel technique for the estimation of muscle mass. The method uses a dose of deuterium-labelled creatine to determine total skeletal muscle mass via estimation of total body creatine pool size.The aim of this study is to compare estimates of total body skeletal muscle mass by D3-creatine dilution method and whole body Magnetic Resonance Imaging (MRI) in an athletic population.

Enrollment: 20 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Trained and competing elite canoe athletes will be recruited, who represent Great Britain Canoeing

Exclusion criteria

• Pregnant and lactating women
• Intolerance or hypersensitivity to Creatine supplementation
• Athletes with disabilities which affect their total body muscle mass
• If creatine was taken in a supplemented form, rather than dietary intake, more regularly than once a week within 6-weeks of assessment commencing
• Contraindication to an MRI scan

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

D3 Creatine followed by creatine supplementation

Experimental group

Description:

Every participant will be orally administered with 60mg of D3 Creatine in a fasted state in a non-gelatin capsule. Creatine supplemented throughout the study will be administered in the following doses-0.03, 0.035, 0.04, 0.045 g.kg.Lean mass/day, increasing on weekly basis. Final dose of 0.05 g.kg.Lean mass/day is then maintained throughout the study.

Treatment:

Dietary Supplement: Creatine

Dietary Supplement: D3 Creatine