NEW MONITORING IN DIFFERENTIAL DIAGNOSIS OF HYPERLACTATHEMIA IN CARDIOPULMONARY BYPASS SURGERY

Acibadem University

Status: Completed

Conditions: Early Period After Cardiopulmonary Bypass Surgery; Washout Phenomenon; Etiology of Hyperlactathemia

Treatments: Device: Near infrared spectroscopy

Study type: Observational

Funder types: Other

Identifiers

NCT04706884

ATADEK 2018-2/21

Details and patient eligibility

About

Objective: The objective of the study was to investigate a reverse correlation between blood lactate levels and rSO2, and distinguish between hypoxic and non-hypoxic hyperlactatemia seen in the early postoperative period.

Full description

The objective of the prospective study was to investigate a reverse correlation between blood lactate levels and rSO2, and distinguish between hypoxic and non-hypoxic hyperlactatemia seen in the early postoperative period.

Sixty American Society of Anesthesiologists (ASA) II-III patients were included in this study. Perioperative data, including age, weight, body surface area, gender, body temperature, preoperative co-morbidities, intraoperative and postoperative hemodynamic parameters, arterial blood gas analysis (ABG), cardiopulmonary bypass and aortic cross-clamp duration, flow rate, urine output, and blood product and inotropic agent usage, were recorded. Postoperative plasma lactate levels were measured simultaneously with cerebral tissue oxygen saturation (rSO2) in both cerebral hemispheres at 10 different time points.

Enrollment: 60 patients

Sex: All

Ages: 43 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA) II-III patients, aged 43-80 years, undergoing on-pump coronary artery bypass grafting

Exclusion criteria

• Active congestive cardiac failure, intraoperative death, urgent cardiac surgery or reoperation, hemodynamic instability or need of inotropic support before the operation, the elevation of any parameters preoperatively suggestive of systemic hypoperfusion, coagulopathy, renal failure, hepatic dysfunction, local or systemic infection, and inflammation.