New Orleans Pulmonary Hypertension Biobank (NO-PH Biobank)

Louisiana State University

Status: Enrolling

Conditions: Healthy; Mixed Connective Tissue Disease; Systemic Sclerosis; Pulmonary Hypertension; Heart Failure With Normal Ejection Fraction

Treatments: Other: No intervention. Biospecimen collection only

Study type: Observational

Funder types: Other

Identifiers

NCT03269630

LSU

Details and patient eligibility

About

Pulmonary hypertension (PH) is a serious condition characterized by a mean pulmonary artery pressure >=25mmHg on right heart catheterization (RHC). Despite advances in PH care, outcomes are still sub-optimal and further research is required into the pathobiology of the disease and development of biomarkers that can guide clinical care. The investigators are establishing a biobank to collect samples (blood, urine, stool) from patients with pulmonary hypertension, patients at high risk for pulmonary hypertension, healthy controls, and patients undergoing right heart catheterization. Specimens will be stored for future investigations.

Enrollment: 450 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Diagnosis of pulmonary hypertension and followed at the Comprehensive Pulmonary Hypertension Center OR
• Diagnosis of systemic sclerosis and followed at the Comprehensive Pulmonary Hypertension Center OR
• Diagnosis of mixed connective tissue disease and followed at the Comprehensive Pulmonary Hypertension Center OR
• Undergoing outpatient right heart catheterization

Exclusion criteria

• Age<18
• Pregnant
• Unable to understand English
• Currently incarcerated
• Unwilling or unable to sign informed consent

Trial design

450 participants in 3 patient groups

Clinic patients (Comprehensive Pulmonary Hypertension Center)

Description:

* Pulmonary hypertension patients (WHO group 1-5) * Systemic sclerosis patients without pulmonary hypertension * Mixed connective tissue disease patients without pulmonary hypertension

Treatment:

Other: No intervention. Biospecimen collection only

Outpatient right heart catheterization patients

Description:

-Outpatients undergoing right heart catheterization for any indication

Treatment:

Other: No intervention. Biospecimen collection only

Healthy controls

Description:

* Age\>18 * Not actively smoking * No chronic medical conditions

Treatment:

Other: No intervention. Biospecimen collection only