New Proteins in Body Fluids as Potential Biomarker for Alzheimer's Disease: a Pilot Study

Universitaire Ziekenhuizen KU Leuven

Status: Unknown

Conditions: Alzheimer Disease, Late Onset

Study type: Observational

Funder types: Other

Identifiers

NCT01773915

s54591

Details and patient eligibility

About

Alzheimer's disease (AD) is the most common neurodegenerative disorder afflicting the elderly. Currently, some biochemical tests performed on Cerebrospinal Fluid (CSF) samples have demonstrated to discriminate to some extend between AD and non-AD individuals based on the levels of tau, phospho-tau or Aβ42. We aim to investigate newly identified proteins whose levels increase during the Braak Stages of AD that are accessible in other body fluids such as blood, urine or saliva. The detection of these proteins would allow performing simple tests in case its levels were confirmed to be associated with the AD pathology.

Full description

We do not desire to provide a more extensive description

Enrollment: 20 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• mild to moderate AD

Exclusion criteria

Trial design

20 participants in 2 patient groups

AD patients

Description:

Subject fulfilling the McKhann criteria for clinical probable AD

Healthy elder persons

Description:

Healthy controls with abscence of any cognitive disorder