New Serological Markers for Eosinophilic Esophagitis

Technical University of Munich

Status: Unknown

Conditions: Eosinophilic Esophagitis

Treatments: Drug: Fluticasone

Study type: Observational

Funder types: Other

Identifiers

NCT01624129

2011_0023

Details and patient eligibility

About

The purpose of the study is to investigate if serological parameters such as "extracellular Serum-Tryptase (ST)" and "eosinophilic cationic protein (ECP)" are useful for the diagnosis and surveillance of the eosinophilic esophagitis (EE).

Full description

The eosinophilic esophagitis (EE) is chronic inflammatory and immunological disease. The diagnosis of EE is based upon large numbers of eosinophils in the esophagus on histopathologic examination (> 20 eosinophils per high powered field in at least one specimen) despite acid suppression with a Proton-Pump-Inhibitor (PPI) for at least two weeks.

There are no diagnostic serological markers for EE so far, so that the purpose of the study is to investigate serological markers which are established in other allergic diseases.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• histopathological defined eosinophilic esophagitis
• Age: 18-80

Exclusion criteria

• missing consent form
• contraindications for performing esophagogastroscopy/taking biopsies of the esophagus

Trial design

20 participants in 1 patient group

eosinophilic esophagitis

Description:

patients with histopathological defined eosinophilic esophagitis

Treatment:

Drug: Fluticasone