New Transporting Solution in Parathyroid Allotransplantation

Sisli Hamidiye Etfal Training and Research Hospital

Status: Unknown

Conditions: Parathyroid Allotransplantation

Treatments: Drug: BAVU Solution

Study type: Interventional

Funder types: Other

Identifiers

NCT02978287

BAVU Solusyon

Details and patient eligibility

About

The aim of this study is to measure of the parathyroid cell viability and the the amount of calcium sensing receptor of the parathyroid cells which were placed into a new transportation solution (BAVU solution) for parathyroid allotransplantation.

Full description

The cold ischemia of organs, has harmful effects on the tissues due to oxidative stress and inflammation. This is physiopathologically defined as ischaemia/re-perfusion injury (IRI) in organ transplantation. Parathyroid allotransplantation has an increased popularity at the last decade. But the cold ischemia due to transportation of the transplant tissue is a very important problem.

Calcium sensing receptor plays a crucial role in regulating Parathormone secretion which means controlling of the calcium-dependent systemic ion homeostasis.

The investigators developed a new tissue transporting solution for parathyroid allotransplantation and the investigators measured the parathyroid cell viability and the the amount of calcium sensing receptor of the parathyroid cells at the 0., 6., 12. and 24. hours of the parathyroid cells which were placed into our new solution.

Enrollment: 7 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who have parathyroid hyperplasia due to chronic renal failure

Exclusion criteria

• Patients who refused to join to the study
• Patients younger than 18 years and older than 80 years.
• Patients who have hepatitis B,
• Patients who have hepatitis C,
• Patients who have human immunodeficiency virus (HIV)

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

---

7 participants in 5 patient groups

BAVU Solution 0. hour (control)

No Intervention group

Description:

Viability, Calcium sensing receptor and parathormone levels of Parathyroid cells at 0. hour

BAVU Solution 6. hour

Experimental group

Description:

Viability, Calcium sensing receptor and parathormone levels of Parathyroid cells at 6. hour

Treatment:

Drug: BAVU Solution

BAVU Solution 12. hour

Experimental group

Description:

Viability, Calcium sensing receptor and parathormone levels of Parathyroid cells at 12. hour

Treatment:

Drug: BAVU Solution

BAVU Solution 18. hour

Experimental group

Description:

Viability, Calcium sensing receptor and parathormone levels of Parathyroid cells at 18. hour

Treatment:

Drug: BAVU Solution

BAVU Solution 24. hour

Experimental group

Description:

Viability, Calcium sensing receptor and parathormone levels of Parathyroid cells at 24. hour

Treatment:

Drug: BAVU Solution