Nexium 40mg Once Daily vs Prevacid 30mg Twice a Day for Control of Severe GERD

Digestive & Liver Disease Specialists

Status and phase

Completed

Phase 4

Conditions

GERD

Treatments

Drug: Antacids

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT00295685

IRUSESOM0159

Details and patient eligibility

About

The purpose of this study is to determine if people taking lansoprazole two times a day to control severe GERD symptoms can be controlled just as well, if not better, by taking Nexium just once a day.

Full description

approximately 20% of patients taking first generation proton pump inhibitors (PPIs) are taking more than the standard approved dose. This dosing is required to attain adequate control of the gastric and intraesophageal pH in order to affect the desired clinical improvement. It is recognized that the b.i.d dosing strategy increases the intragastric pH control of <4 from approximately 12 hours to almost 16 hours. The refinement of the S isomer of omeprazole (Nexium)has led to a way to more effectively control acid exposure. Comparative trials with all the PPIs have shown significantly greater pH control of <4 and head to head comparisons as well as a recent crossover study. One study suggests that Nexium dosing contains approximately 16.5 hours of a pH control of <4. Conceivably, this duration of pH control suggests that b.i.d. dosing of other PPIs might be avoided. Furthermore, it suggests that patients currently taking b.i.d. PPIs might be successful candidates for conversion to q.d. Nexium. This would provide a considerable cost implication to health care plans and for patients who are responsible for paying for their PPI therapy. To date, esomeprazole has not been studied in comparison to b.i.d. dosing with other PPIs. There is pharmacologic evidence to suggest, however, that it is comparable. In this proposed study, we believe that by beginning with patients who were well controlled should make for a cleaner definition and a higher likelihood to demonstrate efficacy.

Enrollment

50 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Previous diagnosis of severe GERD.
Male or female 18-80 years of age
Ability to read, understand and provide informed consent
GERD is Adequately controlled on BID lansoprazole as evidenced by GERD-HRQL score of </= 11
Females of childbearing potential must use an acceptable method of birth control for the duration of the study.

Exclusion criteria

Known contraindications to Nexium
Current or historical evidence of >3 cm histologically confirmed Barrett's metaplasia without current dysplasia, esophageal stricture or extraesophageal GERD symptoms.
Previous Esophageal gastric surgery
Pregnant or nursing Females
Clinically significant abnormal laboratory values
Medical condition that may be adversely impacted by participation in this study
History of or current drug or alcohol abuse
Known malignancy
Need for concurrent therapy with any acid suppressive therapy other than the study drug, antacids, alginates, NSAIDS, >165 mg ASA, prostaglandin analogs, prokinetic drug, antineoplastic agents, Ketoconazole, Itraconazole, Voriconazole, Clarithromycin, Telithromycin, HIV protease inhibitors, Rifampin, Phenobarbital, or Digoxin
Use of investigational drug or experimental device within 30 days prior to screening