Next-Generation Pre-Operative Targeting for Thalamic DBS in the Treatment of Tremor

Mayo Clinic

Status: Completed

Conditions: Essential Tremor

Treatments: Diagnostic Test: Functional MRI

Study type: Interventional

Funder types: Other

Identifiers

NCT03875404

18-010340

Details and patient eligibility

About

Researchers are investigating improved methods of targeting deep brain stimulators for treatment of essential tremor relying on brain connectivity measures derived from MRI.

Enrollment: 9 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of refractory essential tremor scheduled for unilateral thalamic deep brain stimulator placement
• Age ≥ 18 years

Exclusion criteria

• Prior deep brain stimulator, stereotactic radiosurgery, or focused ultrasound procedure for treatment of tremor
• Presence of concomitant movement disorder (e.g. Parkinson's disease, dystonia, etc.)
• Known pre-existing structural brain abnormality (e.g, infarction, tumor, prior brain surgery, etc.)
• Contraindication to 3 Tesla brain MRI (e.g. incompatible implanted device)
• Pregnant

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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9 participants in 1 patient group

Deep Brain Stimulation subjects

Experimental group

Treatment:

Diagnostic Test: Functional MRI