NF2 Natural History Consortium

House Ear Institute

Status: Unknown

Conditions: Meningioma; Schwannoma, Vestibular; Neurofibromatosis 2

Study type: Observational

Funder types: Other

Identifiers

NCT00004483

199/14226

HEI-DAMD17-01-1-0710

HEI-NF2

Details and patient eligibility

About

OBJECTIVES:

I. Define the growth rates and clinical course of NF2-related tumors in patients with neurofibromatosis type 2. Associate growth rate with physical function.

Full description

PROTOCOL OUTLINE: Data on the clinical course and growth rate of NF2-related tumors in patients with neurofibromatosis 2. Patients are evaluated each year on a cranial and a spinal MRI, eye tests, hearing tests, quality of life, neurological tests, and physical functioning.

Sex: All

Ages: 5+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

PROTOCOL ENTRY CRITERIA:

--Disease Characteristics--

• Diagnosed with neurofibromatosis 2 on or after 01/01/93
• Must meet one of the following conditions:

Bilateral vestibular schwannoma OR Family history of neurofibromatosis 2 (first degree family relative) AND Unilateral vestibular schwannoma at under 30 years OR Any 2 of the following: Meningioma Glioma Schwannoma Juvenile posterior subcapsular lenticular opacity/juvenile cortical cataract

• No plans to treat vestibular schwannoma in next 12 months

--Prior/Concurrent Therapy--

• Not specified

--Patient Characteristics--

• Age: 5 and over