NGS-based Large-panel in Targeted Drug Delivery and Immunotherapy of Lung Cancer
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Details and patient eligibility
About
Companion diagnosis by large-panel is in increasing acceptance and need during clinical cancer management. The purpose of this trial is to investigate the benefit of large-panel NGS analysis in companion diagnosis of advanced lung cancer patients and further optimize the parameters.
Full description
Fresh tumor tissues and matched blood cells will be analyzed by large-panel (Berryoncology, lnc.) for multiple molecular biomarkers including mutations with sensitivity/resistance to targeted therapies, tumor mutational burden (TMB), microsatellite instability (MSI) status, etc., Therapeutic approach and outcome will be followed-up to inspect the clinical benefit by large-panel analysis. In addition, selected samples will be analyzed by WES to assess the correctness of TMB estimated by large-panel.
Enrollment
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Volunteers
Inclusion criteria
- Participant aged 18 or above, and gender unrestricted
- Individual with pathologically diagnosed lung cancer
Exclusion criteria
- Patients with concomitant other tumors
- Individual with severe cardiopulmonary insufficiency and hypoproteinemia
- Women who were pregnant and were during their lactation
Trial contacts and locations
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Central trial contact
Niu Xiaomin
Data sourced from clinicaltrials.gov
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