NHF vs. COT in Hypoxemic Pandemic Viral Illness (HIVI)

Jens Bräunlich

Status: Unknown

Conditions: Hypoxemic Respiratory Failure; Hypercapnic Respiratory Failure; Acute Viral Bronchitis

Treatments: Device: Standard oxygen; Device: Nasal high-flow

Study type: Interventional

Funder types: Other

Identifiers

NCT04750408

01

Details and patient eligibility

About

The study compares oxygen and NHF in patients with acute viral illness. The duration will be 72h. After them physiological parameters and the outcome will be evaluated.

Enrollment: 52 estimated patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• acute hyperemic viral illness
• acute hyperemic or hypercapnia respiratory failure

Exclusion criteria

• intubation criteria
• indication for NIV therapy
• influences of primary endpoint (rip fracture, lung embolism)
• tracheostomy
• other interventional trials
• noncompliance

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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52 participants in 2 patient groups

Oxygen use

Active Comparator group

Description:

Patients will use standard oxygen via face mask of nasal prongs as usual care.

Treatment:

Device: Standard oxygen

NHF use

Experimental group

Description:

Patients will use NHF instead of oxygen. Oxygen will be supplemented via the NHF flow.

Treatment:

Device: Nasal high-flow