Niacin Skin Flush Response in Patients With Schizophrenia

Isfahan University of Medical Sciences

Status and phase: Completed; Phase 3; Phase 2

Conditions: Schizophrenia

Treatments: Biological: Niacin skin test

Study type: Interventional

Funder types: Other

Identifiers

NCT02458924

393230

Details and patient eligibility

About

Patients with schizophrenia have abnormal skin flush response to niacin, but the niacin skin test accuracy is not well studied in these patients. The study evaluated the niacin skin test accuracy in adult hospitalized schizophrenia patients and their first degree relatives, bipolar disorder patients, and healthy controls.

Enrollment: 100 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Diagnosis of schizophrenia patients and bipolar disorder patients diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders version IV criteria
• Normal healthy subjects without a psychiatric history
• First degree relatives of schizophrenic patients

Exclusion criteria

• Dermatological lesions, asthma or allergic disease, diabetes, chronic hypertension, vasculitis, substance use disorders (except cigarette smoking), or pregnancy
• Taking any oral medication that could affect the metabolism of prostaglandins such as nonsteroidal anti-inflammatory drugs or corticosteroids

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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100 participants in 4 patient groups

Schizophrenia

Active Comparator group

Description:

Skin niacin test was performed by two concentrations including 0.5 ml solutions of 0.01 M and 0.1 M diluted methyl nicotinate. The two solutions were applied for one minute to the inside of the different forearms of each individual.

Treatment:

Biological: Niacin skin test

Bipolar disorder

Active Comparator group

Description:

Skin niacin test was performed by two concentrations including 0.5 ml solutions of 0.01 M and 0.1 M diluted methyl nicotinate. The two solutions were applied for one minute to the inside of the different forearms of each individual.

Treatment:

Biological: Niacin skin test

First degree relatives

Active Comparator group

Description:

Skin niacin test was performed by two concentrations including 0.5 ml solutions of 0.01 M and 0.1 M diluted methyl nicotinate. The two solutions were applied for one minute to the inside of the different forearms of each individual.

Treatment:

Biological: Niacin skin test

Health controls

Active Comparator group

Description:

Skin niacin test was performed by two concentrations including 0.5 ml solutions of 0.01 M and 0.1 M diluted methyl nicotinate. The two solutions were applied for one minute to the inside of the different forearms of each individual.

Treatment:

Biological: Niacin skin test