Nicardipine Versus Labetalol During Intubation

Seoul National University

Status: Unknown

Conditions: Endotracheal Intubation; Patients Who Are Intubated for General Anesthesia

Treatments: Drug: nicardipine; Drug: labetalol

Study type: Interventional

Funder types: Other

Identifiers

NCT01041066

nicardipine-labetalol

Details and patient eligibility

About

The aim of this study was to compare the efficacy of nicardipine and labetalol in attenuation of cardiovascular responses to endotracheal intubation.

Enrollment: 70 estimated patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients scheduled for general anesthesia with endotracheal intubation

Exclusion criteria

• Patients with heart failure or coronary artery disease 2-3 degree atrio-ventricular block or severe bradycardia (< 45 beats/min) asthma, bronchial spasm or chronic obstructive pulmonary disease patients with anticipated difficult intubation (Mallampati class III, IV) severe hepatic or renal dysfunction allergy or contraindication to study medication

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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70 participants in 2 patient groups

group L

Active Comparator group

Description:

0.4 mg/kg labetalol

Treatment:

Drug: labetalol

group N

Active Comparator group

Description:

20 ㎍/kg nicardipine

Treatment:

Drug: nicardipine