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Nicardipine Versus Labetalol During Intubation

Seoul National University logo

Seoul National University

Status

Unknown

Conditions

Endotracheal Intubation
Patients Who Are Intubated for General Anesthesia

Treatments

Drug: nicardipine
Drug: labetalol

Study type

Interventional

Funder types

Other

Identifiers

NCT01041066
nicardipine-labetalol

Details and patient eligibility

About

The aim of this study was to compare the efficacy of nicardipine and labetalol in attenuation of cardiovascular responses to endotracheal intubation.

Enrollment

70 estimated patients

Sex

All

Ages

20 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients scheduled for general anesthesia with endotracheal intubation

Exclusion criteria

  • Patients with heart failure or coronary artery disease 2-3 degree atrio-ventricular block or severe bradycardia (< 45 beats/min) asthma, bronchial spasm or chronic obstructive pulmonary disease patients with anticipated difficult intubation (Mallampati class III, IV) severe hepatic or renal dysfunction allergy or contraindication to study medication

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

70 participants in 2 patient groups

group L
Active Comparator group
Description:
0.4 mg/kg labetalol
Treatment:
Drug: labetalol
group N
Active Comparator group
Description:
20 ㎍/kg nicardipine
Treatment:
Drug: nicardipine

Trial contacts and locations

1

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Central trial contact

Jung-Hee Ryu, Ph.D

Data sourced from clinicaltrials.gov

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