Nicotinamide Riboside and Metabolic Health

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: Insulin Resistance; Obesity

Treatments: Dietary Supplement: Placebo; Dietary Supplement: Nicotinamide Riboside (Niagen)

Study type: Interventional

Funder types: Other

Identifiers

NCT02835664

NL58119.068.16

Details and patient eligibility

About

This study will investigate the effects of 6 week Nicotinamide Riboside supplementation (1000 mg/day) on metabolic health in healthy (pre)obese humans. The primary objective will be hepatic and whole body insulin sensitivity. Secondary objectives, to provide information about the underlying mechanism, will be muscle mitochondrial function, brown fat activity, ectopic lipid accumulation, energy metabolism, cardiovascular risk parameters, body composition and acetylcarnitine levels.

Enrollment: 15 patients

Sex: All

Ages: 45 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Signed informed consent
• Caucasian
• Males and postmenopausal females
• Aged 45-65 years at start of the study
• Body mass index (BMI) 27 - 35 kg/m2
• Stable dietary habits (no weight loss or gain >5kg in the past 3 months)
• Sedentary lifestyle (not more than 2 hours of sports per week)

Exclusion criteria

• Type 2 diabetes
• Active diseases (cardiovascular, diabetes, liver, kidney, cancer or other)
• Contra-indication for MRI
• Participation in earlier research or medical examination that included PET/CT scanning
• Alcohol consumption of >2 servings per day
• Smoking in the past 6 months

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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15 participants in 2 patient groups, including a placebo group

Nicotinamide Riboside

Experimental group

Description:

Supplementation of Nicotinamide Riboside (Niagen) of 1000 mg/day for 6 weeks. 2 capsules in the morning together with breakfast and 2 capsules around noon together with lunch. Each capsule contains 250 mg.

Treatment:

Dietary Supplement: Placebo

Dietary Supplement: Nicotinamide Riboside (Niagen)

Placebo

Placebo Comparator group

Description:

Supplementation of Placebo of 1000 mg/day for 6 weeks. 2 capsules in the morning together with breakfast and 2 capsules around noon together with lunch. Each capsule contains 250 mg.

Treatment:

Dietary Supplement: Placebo

Dietary Supplement: Nicotinamide Riboside (Niagen)