Nifedipine Versus Magnesium Sulfate for Prevention of Preterm Labor in Symptomatic Placenta Previa

Assiut University

Status and phase

Completed

Phase 3

Conditions

Placenta Previa

Treatments

Drug: Magnesium Sulfate

Drug: Nifedipine

Study type

Interventional

Funder types

Other

Identifiers

NCT03542552

ONIMS

Details and patient eligibility

About

Antepartum hemorrhage is defined as bleeding from or within the female genital tract, occurring from 28+0 weeks of pregnancy and till delivery of the fetus. it occurs in 3-5% of pregnancies and is an important cause of perinatal and maternal morbidity and mortality worldwide

Full description

There are many tocolytic agents may have a role in conservative management of placenta previa such as magnesium sulfate, calcium channel blockers and β-sympathormimetics. In 2004 Sharma suggests that ritodrine hydrochloride in patients with symptomatic placenta previa tends to prolong the pregnancy and result in an increase in birth weight of the babies without causing any adverse effect on the mother and fetus

Enrollment

176 patients

Sex

Female

Volunteers

No Healthy Volunteers

Inclusion criteria

Estimated gestational age : between 28 weeks and 37 week's gestation
Confirmed Placenta previa; either major or minor degrees.
Placenta previa with preterm uterine contractions

Exclusion criteria

Severe attack of bleeding requiring an immediate intervention.
Fetal heart rates instability or non-reassuring tracing
Intrauterine fetal death or major fetal anomalies.
If associated with abruptio placentae
Patients with known bleeding disorders or on anticoagulant therapy
Patients with severe medical disorders as myasthenia gravis documented magnesium toxicity.