NIRS and DO2i Correlation

Centro Cardiologico Monzino

Status: Unknown

Conditions: Perfusion; Complications; Multiorgan Failure

Treatments: Other: DO2i; Procedure: NIRS

Study type: Observational

Funder types: Other

Identifiers

NCT03281707

R627/17-CCM 662

Details and patient eligibility

About

This study evaluates the association between near infrared spectroscopy (NIRS) and indexed oxygen delivery (DO2i) and their possible correlation with postoperative organ failure.

Full description

Literature evidences show that levels of DO2i under 262-272 mL/min/m2 during cardiopulmonary by-pass (CPB) are associated with an increased incidence of acute kidney injury (AKI).

Furthermore, it has been demonstrated that keeping a NIRS of 75-80% compared to the basal value reduces the risk of perioperative morbidity. On the other hand, a NIRS < 50% of basal value seems to be predictive of an increase in morbidity.

All of those studies had been performed during CPB and knowledge lacks in management of DO2i and NIRS before and after CPB.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients undergoing cardiac surgery with cardiopulmonary by-pass whose have been signed the consent informed

Exclusion criteria

• Impossibilty to collect a correct continuous cardiac output measure with PiCCO (chronic atrial fibrillation or severe peripheral vasculopaty)