NIRS to Evaluate Haemodynamic Reserve in Paediatric Moyamoya (NIRS moyamoya)

NHS Foundation Trust

Status: Suspended

Conditions: Moyamoya

Treatments: Device: near infrared spectroscopy

Study type: Interventional

Funder types: Other

Identifiers

NCT05160454

16NC24

Details and patient eligibility

About

Near infrared spectroscpy is a validated method of evaluating cerebral blood flow. The aim in this pilot study to explore its use in children with moyamoya disease.

Full description

Moyamoya disease is a cerebrovascular condition in which there is chronic brain hypoperfusion. As surgery can possibly augment brain blood flow, a method for evalutaing cerebrovascualr reserve would be helpful in selecting patients for intervention.

Near infrared spectroscopy (NIRS) is a validated non-invasive method of evaluating cerebral blood flow. We aim to investigate the feasibility and tolerability of using NIRS haemodynamic reserve in children with moyamoya and controls by evaluating cerebral blood flow in the baseline state and after breath-holding.

Feasibility will be assessed by how many successful studies are carried out. Tolerability will be assessed by asking children some simple questions about their experience.

Enrollment: 20 estimated patients

Sex: All

Ages: 6 to 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: Patients with moyamoya and unaffected healthy controls -

Exclusion Criteria: age <6

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

patient

Active Comparator group

Description:

child with moyamoya

Treatment:

Device: near infrared spectroscopy

control

Active Comparator group

Description:

unaffected control

Treatment:

Device: near infrared spectroscopy