Nitazoxanide as a New Local Adjunctive to Nonsurgical Treatment of Moderate Periodontitis

Maha Talaab

Status and phase: Completed; Phase 2

Conditions: Periodontitis

Treatments: Drug: Nitazoxanide hydrogel; Procedure: Scaling and Root Planing

Study type: Interventional

Funder types: Other

Identifiers

NCT04768530

Nitazoxanide & periodontitis

Details and patient eligibility

About

The aim of the study was to assess the effect of nitazoxanide delivered subgingivally as thermosensitive hydrogel on the clinical and biochemical outcomes of SRP in patients with moderate periodontitis.

Full description

A randomized, controlled clinical trial in a split-mouth design was conducted on forty patients equally divided between two groups: a control group treated with full mouth scaling and root planing (SRP) and a test group treated with SRP combined with subgingivally delivered 0.01% NTZ sustained release Poloxamer 407/hyaluronic acid thermosensitive hydrogel.

Enrollment: 40 patients

Sex: All

Ages: 20 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients having probing depth (PD) ≥5 mm.
• Patients having bleeding on probing (BOP) in proximal tooth surface.
• Patients who could maintain an O'Leary plaque index ≤10 proceeded into the study.

Exclusion criteria

• Patients having any systemic disease that may affect the treatment outcomes.
• Smokers.
• Pregnant females.
• Patients receiving contraindicated medications, chemotherapy, or radiotherapy in the previous year.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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40 participants in 2 patient groups

Scaling and Root Planing (SRP)

Active Comparator group

Treatment:

Procedure: Scaling and Root Planing

Scaling and Root Planing with Nitazoxanide hydrogel

Experimental group

Treatment:

Drug: Nitazoxanide hydrogel