Nitrate Supplementation in Chronic Obstructive Pulmonary Disease (COPD)

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: Chronic Obstructive Pulmonary Disease

Treatments: Dietary Supplement: Placebo supplementation; Dietary Supplement: Nitrate supplementation

Study type: Interventional

Funder types: Other

Identifiers

NCT02084758

ABR-47701

Details and patient eligibility

About

Each subject will consume (in a randomized fashion) both the intervention beverage (nitrate solution) and the placebo, separated by a 1 wk washout period. The investigators will test the hypothesis that 7 days of dietary nitrate supplementation will improve metabolic efficiency in patients with COPD compared to the placebo.

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• COPD
• Indication metabolic inefficiency

Exclusion criteria

• Sodium intake limitation
• Long-term oxygen therapy
• Severe renal impairment
• Use of medications that may interact with nitrate
• Contra-indications for performing (sub)maximal cycle ergometry

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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20 participants in 2 patient groups, including a placebo group

Nitrate supplementation

Active Comparator group

Description:

Sodium nitrate solution

Treatment:

Dietary Supplement: Placebo supplementation

Dietary Supplement: Nitrate supplementation

Placebo supplementation

Placebo Comparator group

Description:

Sodium chloride solution

Treatment:

Dietary Supplement: Placebo supplementation

Dietary Supplement: Nitrate supplementation