Nitrates and IL-8 in Barrett's Esophagus

Mayo Clinic

Status: Terminated

Conditions: Barrett Esophagus; Esophageal Adenocarcinoma

Study type: Observational

Funder types: Other

Identifiers

NCT04642690

20-004618

Details and patient eligibility

About

The purpose of this study is to determine if nitrates and IL-8 (which are found in food and throughout the body regulating stomach acidity) play a role in Barrett's Esophagus and/or Esophageal Adenocarcinoma severity and if screening for these biomarkers can help predict patients that are more at risk for developing worsening disease.

Enrollment: 9 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients undergoing a clinicallly-indicated Esophagogastroduoedoscopy (EGD).

Exclusion criteria

• Comorbid inflammatory medical condition.
• Use of antiinflammatory (aspirin and NSAIDs) or immunosuppressants over the past 1 week.
• Use of nitrate containing medication in the past 1 week.
• Consumption of nitrate rich foods in preceding 24 hours.
• Known allergy to meat or nitrates

Trial design

9 participants in 7 patient groups

Group 1-NSE

Description:

Patients found to have grossly normal squamous epithelium during endoscopy

Group 2-EEG

Description:

Patients found to have grossly apparent erosive esophagitis \>1cm with Los Angeles Classification A-D

Group 3-NDBE Short

Description:

Patients with non-dysplastic Barrett's Esophagus (NDBE) \> 1cm (Short Segment)

Group 4-NDBE Long

Description:

Patients with non-dysplastic Barrett's Esophagus (NDBE) \> 1cm (Long Segment)

Group 5

Description:

Barrett's Esophagus (BE) with high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC)

Group 6-Esophagectomy

Description:

Patients undergoing resection of esophageal cancer

Group -7 Pilot and Feasibility

Description:

Patients undergoing EGD with NSE, NDBE, BE-HGD, or EAC for feasibility of analytical techniques