Nitric Oxide Lung Diffusing Capacity in Healthy, Non-smoking Adults

University of Zurich (UZH)

Status: Completed

Conditions: Healthy

Treatments: Device: Jaeger Masterscreen TM; Device: HypAir Medisoft

Study type: Observational

Funder types: Other

Identifiers

NCT04016597

2019-00226

Details and patient eligibility

About

The measurement of nitric oxide lung diffusing capacity (DLNO) has been recently standardised. To date, two pulmonary function devices are commercially available and are used for the measurement of DLNO. No previous study assessed differences in gas exchange outcomes (e.g., DLNO values) between both devices.

The aim of this project is to compare two commercially available devices that measure lung diffusing capacity for nitric oxide (DLNO).

1. "MasterScreenTM" (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany
2. "HypAir" ("HA", Medisoft, Dinant, Belgium).

Full description

In a single-center, crossover study conducted at the University Hospital Zurich, Switzerland, 35 healthy, non-smoking adults (>=18 years) will be invited to perform DLNO measurements in random order using the MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium) devices during one study visit.

The order of the tests on the MasterscreenTM and HypAir devices will be randomly allocated using central randomisation.

Enrollment: 35 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18 years and older

Exclusion criteria

• Previous thoracic surgery
• Smoking
• Chronic lung disease (e.g., asthma bronchiale, COPD)
• Forced expiratory volume in 1s and/or forced vital capacity below the lower limit of normal based on spirometry [Quanjer et al. Eur Respir J 2005]
• Current respiratory infection

Trial design

35 participants in 1 patient group

Lung diffusing capacity measurements

Description:

Participants perform single-breath lung diffusing capacity measurements in random order during one study visit.

Treatment:

Device: Jaeger Masterscreen TM

Device: HypAir Medisoft