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About
This is a randomized study to treat subjects diagnosed with pulmonary embolism with inhaled nitric oxide or placebo (oxygen).
Full description
This is a randomized, double blind study to treat subjects diagnosed with pulmonary embolism with inhaled nitrix oxide. In this clinical trial investigators will randomized patients to receive inhaled nitric oxide or sham (nitrogen + oxygen) for 24 hours. Patients must have a submassive pulmonary embolism (PE) and evidence of right ventricular (RV) heart dysfunction. Investigators hypothesize that the administration of inhaled NO + oxygen to patients with severe submassive PE will improve RV function, reduce RV strain and necrosis and improve dyspnea (difficulty breathing) more than sham oxygen treatment.
Enrollment
Sex
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Volunteers
Inclusion criteria
Age >/= 18
Pulmonary imaging-proven PE, as interpreted by local radiologist
At least one predictor of RV dysfunction:
Plan to admit to a bed with telemetry capability
Exclusion criteria
Primary purpose
Allocation
Interventional model
Masking
78 participants in 2 patient groups, including a placebo group
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Data sourced from clinicaltrials.gov
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