Nitroglycerine Versus Dexmedetomidine Infusion in Intraoperative Management of Uncontrolled Hypertension

National Cancer Institute, Egypt

Status: Completed

Conditions: Hypertension

Treatments: Drug: Nitroglycerin; Drug: Dexmedetomidine

Study type: Observational

Funder types: Other

Identifiers

NCT04953156

AP2105-50107

Details and patient eligibility

About

This study aim to compare the efficacy of intraoperative dexmedetomidine infusion versus Nitroglycerin infusion in cancer patients with accidental uncontrolled intraoperative elevation of blood pressure.

Full description

Nitroglycerine is a direct vessel wall vasodilator with more venodilator effect than arterial dilator effect. It is used as an anti-anginal and antihypertensive drug. On the other hand, dexmedetomidine is a highly selective alpha 2 adrenergic agonist with sympatholytic effect. This study aim to compare the efficacy of intraoperative dexmedetomidine infusion versus Nitroglycerin infusion in cancer patients with accidental uncontrolled intraoperative elevation of blood pressure.

Enrollment: 77 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Cancer patients with controlled hypertension and undergoing surgical procedures under general anesthesia
• ≥ Age 18 years.

Exclusion criteria

• patient refusal
• patients on Beta blockers
• kidney or liver function impairment
• bradycardia, any degree of heart block and severe cardiorespiratory disease

Trial design

77 participants in 2 patient groups

Nitroglycerin

Description:

data of patients meeting the eligibility criteria and received nitroglycerine infusion will be retrieved from medical records.

Treatment:

Drug: Nitroglycerin

Dexmedetomidine

Description:

patients will receive dexmedetomidine bolus dose of 1 mic/kg over 20 minutes followed by intravenous infusion of 0.2-0.7 mic/kg/hr adjusted according to each patient hemodynamic response

Treatment:

Drug: Dexmedetomidine