NIV Versus HFO Versus Standard Therapy Immediately After Weaning From Mechanical Ventilation in ARDS Patients

Northern State Medical University

Status: Completed

Conditions: Weaning Failure; Mechanical Ventilation Complication; Acute Respiratory Distress Syndrome; High-flow Oxygenation

Treatments: Device: Respiratory support

Study type: Interventional

Funder types: Other

Identifiers

NCT06332768

WEAN_2021

Details and patient eligibility

About

The weaning failure is a paramount challenge when aggressive discontinuation of respiratory support in ARDS. The aim of the study is to improve weaning safety and efficacy by a transient postextubation non-invasive respiratory support.

Full description

HFNO (high-flow nasal oxygenation and NIV (non invasive ventilation) are to be randomly compared in the ARDS postextubation period.

Enrollment: 60 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

ARDS

Exclusion criteria

Severe ICU-aquired weakness Severe COPD

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

NIV

Active Comparator group

Description:

Non-invasive ventilation

Treatment:

Device: Respiratory support

HFO

Active Comparator group

Description:

High Flow Oxygenation

Treatment:

Device: Respiratory support