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NKG2D CAR-NK Cell Therapy in Patients With Relapsed or Refractory Acute Myeloid Leukemia

H

Hangzhou Cheetah Cell Therapeutics

Status

Terminated

Conditions

Safety and Efficacy

Treatments

Biological: CAR-NK cells

Study type

Interventional

Funder types

Other

Identifiers

NCT05247957
CARNK-001

Details and patient eligibility

About

This trial will explore the maximum tolerated dose of cord blood NKG2D CAR-NK in the treatment of recurrent refractory acute myeloid leukemia in a dose-escalation manner, and observe its clinical safety and efficacy.

Full description

This is a single arm, open-label, Phase 1 study initiated with 3 cohorts:

Cohort 1: 2×10∧6/kg CAR-NK cells, 2 infusions on Day 0 and Day 7 Cohort 2: 6×10∧6/kg CAR-NK cells, 2 infusions on Day 0 and Day 7 Cohort 3: 18×10∧6/kg CAR-NK cells, 2 infusions on Day 0 and Day 7

Enrollment

9 patients

Sex

All

Ages

10 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  1. Age: ≥ 10 years old and ≤ 75 years old, male or female;
  2. Meet the diagnostic criteria for recurrent AML: detection of leukemia cells after complete remission (CR) or >0.1% of leukemia cells in bone marrow, including recurrence after allogeneic hematopoietic stem cell transplantation, or extramedullary infiltration of leukemia cells;
  3. Initial cases with failure of 2 lines of standard treatment; patients who relapsed within 12 months after consolidation intensification after CR; recurrence in 12 months and no respond to conventional chemotherapy; 2 or more recurrences; persistent extramedullarial leukemia;
  4. Patients currently have no effective treatment options, such as chemotherapy or allogeneic hematopoietic stem cell transplantation, or patients voluntarily choose to infuse NKG2D CAR-NK cells as the first treatment option;
  5. Physical status assessment (ECOG-PS) of the Eastern Oncology Collaborative Group is 0-2 points;
  6. Estimated survival > 3 months
  7. Flow cytometry check for NKG2D ligand expression on the surface of cancer cells for a reference of selecting patients
  8. The main organs of the patient are well functioned: (1) cardiac function: no heart disease or coronary heart disease, the patient's cardiac function grade 1-2; (2) liver function: TBIL≦3ULN, AST≦2.5ULN, ALT≦2.5ULN; (3) Renal function: Cr≦1.25ULN;
  9. The patient's peripheral superficial vein can meet the needs of intravenous injection;
  10. No other serious diseases that conflict with this protocol (e.g., autoimmune diseases, immunodeficiency, organ transplantation);
  11. No history of other malignant tumors;
  12. Women of childbearing age must be tested negative for pregnancy within 7 days, and subjects of childbearing age must use appropriate contraception during both the trial and for 3 months after the test;
  13. Subjects have negative HIV, HBV, HCV, syphilis serology test results
  14. Written informed consent form must be signed before enrollment.

Exclusion criteria

  1. Acute promyelocytic leukemia (type M3);
  2. Patients with cardiac insufficiency, patients with hepatic and renal insufficiency;
  3. Those who need treatment with other malignant tumors;
  4. Poorly controlled hypertension (systolic blood pressure >160 mmHg and/or diastolic blood pressure >90 mmHg) or clinically significant cardiovascular and cerebrovascular diseases such as cerebrovascular accident (within 6 months before signing the informed consent form), myocardial infarction (within 6 months before signing the informed consent), unstable angina, congestive heart failure, or severe arrhythmias that cannot be controlled with drugs or have a potential impact on research treatment;
  5. Also suffering from other hematologic diseases (such as hemophilia, myelofibrosis, etc., which researchers consider unsuitable for inductees);
  6. Diffuse vascular internal coagulation;
  7. Concomitant serious infection or other serious underlying medical condition;
  8. Have immunodeficiency and autoimmune diseases;
  9. Have severe allergic diseases;
  10. Clinical symptoms of brain dysfunction or severe mental illness that can not understand or follow the research protocol;
  11. Have participated in clinical trials of other drugs within 4 weeks or within 21 days of surgery;
  12. Have received cell therapy in the previous 1 month;
  13. Have received hormonal drug therapy in the previous 14 days;
  14. Known HIV-positive patients or hepatitis B and C patients and syphilis patients;
  15. Have received organ transplants (excluding stem cell transplant patients);
  16. Drug abuse, medical, psychological or social conditions that may interfere with a subject's participation in the study or evaluation of the results of the study;
  17. Pregnant or lactating women;
  18. Those who cannot be followed up as scheduled;
  19. Investigator considers that the subject has any clinical or laboratory abnormalities or compliance problems and is not suitable to participate in this clinical study.

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

9 participants in 1 patient group

NKG2DL-specific CAR-NK cells
Experimental group
Description:
Experimental: NKG2DL-specific CAR-NK cells, 2 infusions on Day 0 and Day 7 After preconditioning with chemotherapy, NKG2DL-specific CAR-NK cells will be evaluated
Treatment:
Biological: CAR-NK cells

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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