NLCR in Prediction of the Grade of Lung Tumor.

Medical University of Silesia

Status: Completed

Conditions: Lung Neoplasm

Treatments: Diagnostic Test: Complete blood count; Other: Histopathological examination

Study type: Observational

Funder types: Other

Identifiers

NCT03749512

NLCR-01

Details and patient eligibility

About

The aim of the study is to assess whether the value of neutrophil-lymphocyte count ratio from the routine preoperative blood test may predict lung tumors' grading.

Full description

Lung cancer remains as one of the leading causes of death among oncology patients. Close connection between inflammation and pathogenesis of some neoplasms was determined in a number of studies. Some studies show promise that ratio of neutrophil to lymphocyte count (NLCR) may be recognized as a prognostic marker for several carcinomas: renal, lung and colorectal. The aim of the study is to assess whether the value of neutrophil-lymphocyte count ratio from the routine preoperative blood test may predict lung tumors' grading. During routine preoperative blood tests complete blood count is done and NLCR, WBC, neutrophil and lymphocyte count is noted. After the thoracic surgery intervention and histopathological examination grading of lung tumor is noted.

Enrollment: 400 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• consecutive thoracic surgery patients with lung cancer grading confirmed by histopathology postoperatively
• preoperative routine complete blood count analysis

Exclusion criteria

• infectious disease
• pregnancy
• autoimmunologic disease
• other known conditions or treatments that may influence the blood count (seropositivity for HIV, chemotherapy, and corticotherapy)

Trial design

400 participants in 1 patient group

Observational Group

Description:

Group of patients with lung tumor qualified for thoracic surgery intervention with routine, preoperative complete blood count test and routine postoperative histopathological examination of lung tumor.

Treatment:

Diagnostic Test: Complete blood count

Other: Histopathological examination