NLR and PLR Levels Following PENG Block in Hip Arthroplasty

Poznan University of Medical Sciences (PUMS)

Status and phase: Completed; Phase 4

Conditions: Hip Arthropathy; Hip Osteoarthritis; Hip Pain Chronic

Treatments: Drug: 0.9% Sodium Chloride Injection; Drug: Ropivacaine 0.2% Injectable Solution

Study type: Interventional

Funder types: Other

Identifiers

NCT07023107

7/2025

Details and patient eligibility

About

Effect of PENG block on NLR and PLR following hip arthroplasty

Full description

The NLR is a sensitive indicator of inflammation confirmed in numerous studies and has a predictive and prognostic value. NLR is a cheap, simple, fast-acting, readily available stress and inflammation parameter with high sensitivity and low specificity. Dynamic changes in the NLR precede the clinical state by several hours and may alert clinicians to the ongoing pathological process early. NLR is a new promising marker of cellular immune activation, an important indicator of stress and systemic inflammation. It opens a new dimension for clinical medicine, enabling a better understanding of the biology of inflammation, the linkage and antagonism between innate and adaptive immunity, and their clinical consequences for health and disease.

NLR is affected not only by surgical trauma but also by the method of anesthesia. In recent years, the influence of regional anesthesiology on reducing the inflammatory response after surgical procedures has been emphasized. However, there have been very few studies evaluating the effect of various methods of anesthesia on the NLR.

Enrollment: 60 patients

Sex: All

Ages: 60 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with ASA classification I-III
• Aged 60-100 years
• Who will be scheduled for hip arthroplasty under spinal anesthesia

Exclusion criteria

• Patients who have a history of bleeding diathesis
• Take anticoagulant therapy
• History of chronic pain before surgery
• Multiple trauma
• patients unable to assess their pain (dementia)
• patients operated under general anesthesia
• patients having an infection in the region of the procedure
• the patient who does not accept the procedure

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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60 participants in 2 patient groups, including a placebo group

Sham blocks

Placebo Comparator group

Description:

PENG block with 20ml of 0.9% sodium chloride

Treatment:

Drug: 0.9% Sodium Chloride Injection

PENG block

Active Comparator group

Description:

PENG block with 20ml 0f 0.2% ropivacaine

Treatment:

Drug: Ropivacaine 0.2% Injectable Solution