NLR and PLR Levels Following IPACK Block in Knee Arthroplasty

Poznan University of Medical Sciences (PUMS)

Status and phase: Completed; Phase 4

Conditions: Knee Pain Chronic; Knee Osteoarthritis; Knee Arthropathy

Treatments: Drug: 0.9% Sodium Chloride Injection; Drug: Ropivacaine 0.2% Injectable Solution

Study type: Interventional

Funder types: Other

Identifiers

NCT06304298

10/2023

Details and patient eligibility

About

Effect of iPACK block on NLR and PLR following knee arthroplasty

Full description

The NLR is a sensitive indicator of inflammation confirmed in numerous studies and has a predictive and prognostic value. NLR is a cheap, simple, fast-acting, readily available stress and inflammation parameter with high sensitivity and low specificity. Dynamic changes in the NLR precede the clinical state for several hours and may alert clinicians early about the ongoing pathological process. NLR is a new promising marker of cellular immune activation, an important indicator of stress and systemic inflammation. It opens a new dimension for clinical medicine to understand better the biology of inflammation, the linkage, and antagonism between innate and adaptive immunity, and its clinical consequences for health and disease.

NLR is affected not only by surgical trauma but also by the method of anesthesia. In recent years, the influence of regional anesthesiology on reducing the inflammatory response after surgical procedures has been emphasized. However, there have been very few studies evaluating the effect of various methods of anesthesia on the NLR.

This is the first study to investigate the effect of regional anesthesia on the NLR and PLR in patients undergoing knee replacement surgery.

Enrollment: 60 patients

Sex: All

Ages: 20 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with ASA classification I-III
• Aged 20-90 years
• Who will be scheduled for hip arthroplasty under spinal anesthesia

Exclusion criteria

• Patients who have a history of bleeding diathesis
• Take anticoagulant therapy
• History of chronic pain before surgery
• Multiple trauma
• patients unable to assess their pain (dementia)
• patients operated under general anesthesia
• patients having an infection in region of the procedure
• patient who do not accept the procedure

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 2 patient groups

Sham blocks

Active Comparator group

Description:

iPACK block with 20ml of 0.9% sodium chloride

Treatment:

Drug: 0.9% Sodium Chloride Injection

iPACK block

Active Comparator group

Description:

iPACK block with 20ml 0f 0.2% ropivacaine

Treatment:

Drug: Ropivacaine 0.2% Injectable Solution