NLR and Sevoflurane Use in Ear Surgeries: Flow Comparison (ANFLUX)

Eda KAZANÇ ÖZDEN

Status: Completed

Conditions: High-flow Anesthesia; Tympanoplasty; Myringoplasty; Low-flow Anesthesia; Neutrophil-to-Lymphocyte Ratio

Study type: Observational

Funder types: Other

Identifiers

NCT07064642

EKO-NLR-2025

2023/122 (Other Identifier)

Details and patient eligibility

About

This retrospective study aims to compare the effects of low-flow and high-flow anesthesia techniques on intraoperative hemodynamics, neutrophil-to-lymphocyte ratio (NLR), and postoperative outcomes in patients undergoing tympanoplasty or myringoplasty. The data were collected from medical records of patients who underwent ear surgery between [September 1, 2022] and [April 1, 2023]. The study seeks to evaluate whether the choice of anesthetic flow rate has a significant impact on inflammatory response and recovery.

Full description

This study investigates the influence of anesthetic gas flow rates on systemic inflammation and hemodynamic stability in middle ear surgeries. While low-flow anesthesia is associated with reduced environmental exposure and cost-effectiveness, its impact on inflammatory markers and recovery outcomes remains less clearly defined. The neutrophil-to-lymphocyte ratio (NLR) is used as a readily available, cost-effective biomarker of systemic inflammation. This study retrospectively analyzes perioperative data from patients who underwent tympanoplasty or myringoplasty, comparing NLR levels, intraoperative vital signs, and postoperative recovery parameters between low-flow and high-flow anesthesia groups. The results may contribute to optimizing anesthetic strategies in otologic surgeries, with emphasis on inflammation modulation and patient safety.

Enrollment: 50 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults aged between 18 and 75 years
• American Society of Anesthesiologists (ASA) physical status classification I to III
• Body Mass Index (BMI) between 18.5 and 29.9 kg/m²

Exclusion criteria

• Age below 18 or above 75 years
• Incomplete or missing clinical data
• BMI less than 18.5 kg/m² or greater than 29.9 kg/m²
• Presence of neurological disorders
• History of renal or hepatic failure

Trial design

50 participants in 2 patient groups

Low-flow anesthesia group

Description:

Low-flow anesthesia group 0.75 L/min : Patients who underwent tympanoplasty or myringoplasty under low-flow anesthesia technique. The anesthetic gas flow rate was maintained at low levels throughout the procedure to evaluate its effects on systemic inflammation and hemodynamics.

High-flow anesthesia group

Description:

High-flow anesthesia group 3 L/min : Patients who underwent tympanoplasty or myringoplasty under high-flow anesthesia technique. The anesthetic gas flow rate was maintained at high levels throughout the procedure to compare its impact on inflammatory response and postoperative outcomes.