NLRP3 Inflammasome Activation Among Patients During Acute Gout Flares (ActiNG)

Centre Hospitalier Saint Joseph Saint Luc de Lyon

Status: Enrolling

Conditions: Gout Arthritis

Study type: Observational

Funder types: Other

Identifiers

NCT05744297

ActiNG

Details and patient eligibility

About

Gout is a chronic joint disease associated with deposition of monosodium urate crystals, as a consequence of hyperuricemia. Gout is an intermittent flaring condition and acute gout flares are driven by NLRP3 inflammasome and IL1-beta production.

However pathogenesis of acute gout flares remains poorly known in vivo in human.

The aim of this study is to evaluate NLRP3 inflammasome activation in vivo in patients cells during acute gout flares.

Full description

Blood and synovial fluid will be obtained from remainder of patients' samples during an acute gout flares. White blood cells will be isolated and NLRP3 inflammasome activation will be assessed. Then, NLRP3 inflammasome inhibitors will be tested on cells with NLRP3 inflammasome activity.

Enrollment: 10 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Hospitalization for acute gout flare confirmed by joint fluid analysis or Nijmegen score > 8
• Aged > 18

Exclusion criteria

• Gout treatment already started
• Inflammatory Arthritis other than Gout Arthritis
• Pregnant or breast feeding women
• Patient protected by law