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NOAC9 - Circulating Tumor DNA Guided Follow-Up in Anal Cancer

A

Aarhus University Hospital

Status

Enrolling

Conditions

Anal Cancer

Treatments

Diagnostic Test: AMR B: HPV positive ctDNA guided imaging in follow-up

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

This study investigates if circulating tumor DNA can improve the detection of early treatment failure or recurrence in localized squamous cell carcinoma of the anus (SCCA) after curative chemoradiotherapy thereby increasing the potential for cure. This will be done by comparing the standard follow-up program with ctDNA guided imaging follow-up. Secondly, the aim is to establish early interventions against late morbidities.

Full description

Squamous cell carcinoma of the anus (SCCA) is a rare disease with less than 200 new cases in Denmark and Sweden each year and approximately 100 new cases in Norway and Finland but with increasing incidence. Primary treatment is chemo-radiotherapy (CRT) comprising high dose IMRT based radiation therapy with combination chemotherapy of 5-FU and Cisplatin. Overall treatment response is good in small tumors, but less pronounced for high-risk tumors.

In absence of complete pathological response after CRT or local recurrence, patients are evaluated for. salvage surgery. The importance of R0 resection on overall survival has been described in several studies. It is suggested that early detection of treatment failure and recurrences increases the chance of possible curative surgery (R0-resection) and thereby overall survival.

A follow-up program has 3 purposes

  1. To detect lack of complete response to primary treatment
  2. Early detection of local or distant recurrences
  3. Describing and managing late morbidity

Purpose:

The main purpose of this follow-up study is to investigate if circulating tumor tDNA can improve detection of early treatment failure or recurrences thereby assisting in increasing the potential for cure. Secondly, to provide evidence for use of imaging and third objective is to establish early intervention against late morbidities.

Enrollment

400 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients with SCCA eligible for definitive (chemo)radiotherapy
  • ≥ 18 of years
  • Written and oral consent

Exclusion criteria

  • Conditions that will contraindicate blood samples
  • Conditions that will contraindicate a PET-CT scan.
  • Potential lack of compliance to standard FU program and study participation.

Trial design

Primary purpose

Diagnostic

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

400 participants in 3 patient groups

ARM A: HPV positive standard of care follow-up
No Intervention group
Description:
The national follow-up program + collection of blood samples for retrospective translational research
ARM B: HPV positive ctDNA guided imaging in follow-up
Experimental group
Description:
The national follow-up program + ctDNA guided additional imaging + collection of blood samples for retrospective translational research
Treatment:
Diagnostic Test: AMR B: HPV positive ctDNA guided imaging in follow-up
ARM O: HPV negative observational arm
No Intervention group
Description:
Patients with HPV negative disease will be included in an observational arm (ARM O) ARM O: The national follow-up program + collection of blood samples for retrospective translational research

Trial contacts and locations

13

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Central trial contact

Karen-Lise G Spindler, Professor; Louise V Laursen, Secretary

Data sourced from clinicaltrials.gov

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