Nocturnal Continuous Positive Airway Pressure in Chronic Obstructive Pulmonary Disease Patients

Centre Hospitalier Universitaire Saint Pierre

Status: Withdrawn

Conditions: Chronic Obstructive Pulmonary Disease

Treatments: Device: continuous positive airway pressure

Study type: Interventional

Funder types: Other

Identifiers

NCT02884830

AK/16-05-73/4668AD

Details and patient eligibility

About

Static hyperinflation is frequent in Chronic obstructive pulmonary disease (COPD) , resulting in increased end expiratory lung volume and positive end expiratory pressure (PEEPi) at the end of a normal expiration.

Static hyperinflation worsens the work of breathing is increases patient's dyspnea.

The application of a continuous positive airway pressure (CPAP) has been shown to improve static hyperinflation and to decrease the work of breathing.

Sleep is deteriorated in COPD patients, and causal factors includes static hyperinflation. The purpose of our study is to assess the effect of nocturnal CPAP on sleep quality and functional respiratory parameters.

Full description

Chronic obstructive pulmonary disease (COPD) is characterized by an airflow obstruction, inducing a flow limitation. As a consequence, we observe in these patients an increased end expiratory lung volume and a positive end expiratory pressure (PEEPi) at the end of a normal expiration.

Patients are breathing at higher pulmonary volumes: this is the concept of static hyperinflation.

This worsens the breathing pattern because in this situation, the work of breathing is increased such that dyspnea increases.

The application of a continuous positive airway pressure (CPAP) has been shown to improve static hyperinflation and to decrease the work of breathing.

Sleep is deteriorated in COPD patients, and causal factors includes static hyperinflation, cough, depression. Moreover, normal physiological changes occuring during sleep in COPD patients are leading to deterioration of gaseous exchanges. The purpose of our study is to assess the effect of nocturnal CPAP on sleep quality and functional respiratory parameters.

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• stable chronic obstructive pulmonary disease patients exhibiting a FEV1<80 %,

Exclusion criteria

• Known sleep apnea syndrome or other sleep disease interfering with sleep quality
• Body mass index > 30 kg/m2
• heart failure
• hypnotics intake

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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0 participants in 2 patient groups, including a placebo group

Sham CPAP

Placebo Comparator group

Description:

Sham continuous positive airway pressure is a CPAP given at too low pressure to have any physiological effect on upper airways patency and on lung volumes

Treatment:

Device: continuous positive airway pressure

Efficace CPAP

Active Comparator group

Description:

Continuous positive airway pressure is a CPAP given at effective pressure to decrease the work of breathing in COPD patients

Treatment:

Device: continuous positive airway pressure