Nocturnal Hypertension and Non-Dipping Blood Pressure

The University of Alabama at Birmingham

Status: Completed

Conditions: Hypertension; Obstructive Sleep Apnea

Treatments: Dietary Supplement: Dietary sodium

Study type: Interventional

Funder types: Other

Identifiers

NCT03128177

F150508004

Details and patient eligibility

About

The purpose of this study is to determine if high salt diet contributes to high nighttime blood pressure. The investigators will determine if high compared to low salt diet increases 24-hour blood pressure levels. The investigators will also determine if high salt diet affects blood vessel stiffness, cardiac output, and sleep apnea. The study will also determine how high salt diet affects the activity of certain genes related to control of blood pressure. A total of 60 participants will be enrolled in the study.

Enrollment: 59 patients

Sex: All

Ages: 48 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Nocturnal hypertension

Exclusion criteria

• Stage 2 clinic hypertension
• History of congestive heart failure
• Chronic kidney disease,
• Diabetes with insulin use
• History of a cardiovascular event
• Pregnant or nursing
• Current use of continuous positive airway pressure
• Shift work
• A known circadian rhythm disorder

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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59 participants in 2 patient groups

High sodium diet

Experimental group

Description:

High sodium diet is 6 g sodium per day for 10 days

Treatment:

Dietary Supplement: Dietary sodium

Low sodium diet

Experimental group

Description:

Low sodium diet is 1.5 g sodium per day for 10 days

Treatment:

Dietary Supplement: Dietary sodium