Nocturnal Oxygen Treatment in Heart Failure and Cheyne-Stokes Respiration

Umeå University

Status: Completed

Conditions: Heart Failure

Treatments: Device: nocturnal oxygen treatment from oxygen concentrators

Study type: Interventional

Funder types: Other

Identifiers

NCT00338078

241/98, dnr 98-165

Details and patient eligibility

About

The purpose of this study is to determine whether oxygen therapy during sleep improves quality of life, exercise capacity and heart function among patients with chronic heart failure and central sleep apnea.

Full description

Oxygen therapy reduces the number of central apneas among patients with congestive heart failure but it is unknown whether quality of life and heart function also improve. We aim to test whether the quality of life, exercise capacity and heart function are improved with nocturnal oxygen therapy during 6 weeks with nocturnal oxygen from oxygen concentrator or nocturnal air from placebo concentrator.

Enrollment: 62 patients

Sex: All

Ages: 19 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Stable heart failure with left ventricular dysfunction
• Cheyne-Stokes respiration with central AHI>15 and obstructive AHI<5

Exclusion criteria

• Heart infarction within 3 months.
• Dementia
• Chronic obstructive pulmonary disease and daytime hypoxemia.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind