Non-coding RNA in the Exosome of the Epithelia Ovarian Cancer

Lei Li

Status: Unknown

Conditions: Early Diagnosis; High Grade Serous Carcinoma; Exosomes; Ovarian Cancer; Prognosis

Treatments: Genetic: Sequencing of miRNA/lncRNA

Study type: Observational

Funder types: Other

Identifiers

NCT03738319

EOC-EXOSOME

Details and patient eligibility

About

This study aims to analyze the expression of micro-RNA (miRNA) and long non-coding RNA (lncRNA) by next-generation sequencing in patients with high grade serous ovarian cancer (HGSOC) and benign gynecologic diseases. The candidate miRNA/lncRNA will be validated as biomarker for the detection and prognosis of HGSOC.

Enrollment: 160 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Confirmed primary high grade serous ovarian cancer
• Willing to accepted debulking surgeries and adjuvant chemotherapy
• Good performance status
• Aged 18 years or older
• Signed an approved informed consents

Exclusion criteria

• Not meeting all of the inclusion criteria

Trial design

160 participants in 2 patient groups

HGSOC group

Description:

This group includes patients of high grade serous ovarian cancer (HGSOC).

Treatment:

Genetic: Sequencing of miRNA/lncRNA

Control group

Description:

This group includes patients of benign gynecologic diseases as control.

Treatment:

Genetic: Sequencing of miRNA/lncRNA