Non-Helium Magnetoencephalography in Pediatric Refractory Epilepsy

Guangzhou Women and Children's Medical Center

Status: Enrolling

Conditions: Refractory Epilepsy in Children

Treatments: Diagnostic Test: Stereo-electroencephalography/Electrocorticography; Diagnostic Test: Magnetoencephalography plus Stereo-electroencephalography/Electrocorticography

Study type: Observational

Funder types: Other

Identifiers

NCT07064421

446A01

Details and patient eligibility

About

The goal of this observational study is to evaluate the effectiveness of Magnetoencephalography (MEG) in the preoperative assessment of children with refractory epilepsy, particularly in identifying the seizure focus, and to compare it with the gold standard methods of Stereo-electroencephalography (SEEG) and Electrocorticography (ECoG).

The main questions this study aims to answer are:

1. How consistent is MEG with SEEG/ECoG in locating the epileptic focus in children with refractory epilepsy?
2. What is the clinical efficacy of MEG in identifying epileptic foci?

Participants will:

1. Be divided into 2 groups: the case group and the control group. Participants in the case group will undergo both MEG and SEEG/ECoG for preoperative assessment, while patients in the control group will undergo only SEEG/ECoG before surgery.
2. Be followed up at 1, 3, 6, and 12 months after surgery to assess seizure control, neurological function, and quality of life.

Enrollment: 100 estimated patients

Sex: All

Ages: 3 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age range: 3-18 years old;
2. Clinically diagnosed with refractory epilepsy;
3. Capable of cooperating with magnetoencephalography evaluation and recording.

Exclusion criteria

1. Patients with serious comorbidities or neurological or psychiatric disorders that affect magnetoencephalography examination.
2. Patients using drugs that affect central nervous system function;
3. Patients who are not suitable for surgical procedures;
4. Patients with progressive neurological disorders.

Trial design

100 participants in 2 patient groups

Case

Description:

Participants in the case group will undergo both MEG and SEEG/ECoG for preoperative assessment.

Treatment:

Diagnostic Test: Magnetoencephalography plus Stereo-electroencephalography/Electrocorticography

Control

Description:

Patients in the control group will undergo only SEEG/ECoG before surgery.

Treatment:

Diagnostic Test: Stereo-electroencephalography/Electrocorticography