Non-hypovascular Solid Pancreatic Lesions: Role of EUS (LE-VASC)

Integrated University Hospital Trust of Verona

Status: Completed

Conditions: Solid Pancreatic Neoplasms; Endoscopic Ultrasound

Treatments: Diagnostic Test: Endoscopic ultrasound-fine needle biopsy

Study type: Observational

Funder types: Other

Identifiers

NCT03738280

1296CESC

Details and patient eligibility

About

Vascular pattern of solid pancreatic lesions (SPLs) has been investigated by different abdominal imaging modalities and by contrast-enhanced endoscopic ultrasonography (CE-EUS). Compared with surrounding pancreatic parenchyma three different patterns have been described: hypo-, iso-, and hypervascular. The majority of SPLs are hypovascular, and the diagnostic relevance of hypoenhanced pattern to predict pancreatic adenocarcinoma (PDAC) is well established. Differently, iso- and hypervascular pattern is not specific and can be expressed by several SPLs, with different clinical behavior and management. To date, poor is know about the role of EUS in differential diagnosis of non-hypovascular SPLs and features associated with malignancy.

Enrollment: 154 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Presence of one or more solid pancreatic lesions preliminary evaluated by contrast-enhanced computed tomography (CE-CT) and/or contrast enhanced magnetic resonance imaging (CE-MRI) reporting a non-hypovascular contrast pattern (e.g., iso- or hypervascular).

Exclusion criteria

• Patients with associated chronic pancreatitis features (e.g., pancreatic calcifications)
• Lesion with hypovascular pattern at CE-EUS.
• Lesion not found or non pancreatic at EUS.
• Patients refusing to be included in the study