Non-inferiority Study of Ocrelizumab and Rituximab in Active Multiple Sclerosis (DanNORMS)

Rigshospitalet

Status and phase

Active, not recruiting

Phase 3

Conditions

Primary Progressive Multiple Sclerosis

Secondary Progressive Multiple Sclerosis

Relapsing Remitting Multiple Sclerosis

Treatments

Drug: Rituximab

Drug: Ocrelizumab

Drug: Fexofenadine

Drug: Paracetamol

Drug: Methylprednisolone

Study type

Interventional

Funder types

Other

Identifiers

NCT04688788

DanNORMS_version 3.2

Details and patient eligibility

About

The DanNORMS study is a phase 3, non-inferiority clinical trial examining whether treatment of active multiple sclerosis with rituximab is non-inferior to ocrelizumab regarding efficacy and safety.

Full description

The DanNORMS study will include patients with active multiple sclerosis aged 18-65 years. Patients will be randomized in a 2:1 ratio to either rituximab or ocrelizumab. The study duration is 24 months for the core-phase, and patients can continue in a long-term follow-up phase for additional 36 months with possibility for extended interval dosing guided by CD19+ B cell count.

The primary endpoint is the percentage of patients without new or enlarging T2 white matter lesions on brain MRI scans from month 6 to month 24, which will be assessed by radiologists blinded to the treatments status. The study will evaluate a number of efficacy and safety endpoints using clinical, MRI, routine blood samples and research biomarkers.

Enrollment

600 patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

MS diagnosis and definition of disease course according to the 2017 McDonald criteria
Expanded disability status scale (EDSS) ≤6.5
Fulfilling criteria for active MS:
- Treatment naïve relapsing remitting multiple sclerosis (RRMS) patients (never treated, or no DMT the previous 2 years):
  1. ▪≥2 relapse previous 12 months OR
  2. 1 relapse previous 12 months with severe residual symptoms and EDSS ≥ 3.0 OR
  3. 1 relapse previous 12 months AND ≥9 T2 lesions on brain and/or spinal cord MRI AND
    - 1 contrast-enhancing lesion or ≥1 new or enlarging T2 lesion on brain and/or spinal cord MRI previous 12 month
- Previously treated RRMS patients:
  1. ≥1 relapse previous 12 months OR
  2. ≥1 contrast-enhancing lesion or ≥2 new/enlarging T2 lesions on brain and/or spinal cord MRI previous 12 months
- Progressive MS patients:
  1. ≥1 relapse previous 12 months OR
  2. ≥1 contrast-enhancing lesion previous 12 months or ≥1 new/enlarging T2 lesions on brain and/or spinal cord MRI previous 12 months or ≥2 new or enlarging T2 lesion on brain and/or spinal cord MRI previous 24 months OR
  3. Increased levels of neurofilament light chain (NFL) in serum or cerebrospinal fluid (CSF) in sample collected previous 12 months. Progressive MS patients not fulfilling the clinical/MRI criteria for active disease, may qualify for inclusion in the study if:
    
    (A) CSF NFL level (measured with NF-Light® ELISA assay from Uman Diagnostics or Simoa):
    - 18 to 40 years >560 ng/l
    - 41 to 60 years >890 ng/l
    - 61 to 65 years >1850 ng/l
    or
    
    (B) Serum NFL level (measured with Simoa™ NF-light® Advantage Kit)
    
    o Increased sNFL based on individual age-determined cut-off: >4.19 × 1.029^age ng/L
    
    OR
    
    o Increased sNFL based age-partitioned cut-offs:
    - 18 to 20 years >7.4 ng/L
    - 21 to 30 years >9.9 ng/L
    - 31 to 40 years >13.1 ng/L
    - 41 to 50 years >17.5 ng/L
    - 51 to 60 years >23.3 ng/L
    - 61 to 65 years >30.9 ng/L
Signed written informed consent

Exclusion criteria

Pregnancy or breast feeding
Lack of effective contraception for women of child-bearing potential (effective contraception include oral contraception, intrauterine devices and other forms of contraception with failure rate <1%)
Receipt of a live or live-attenuated vaccine within 6 weeks prior to randomization
Known active malignant disease
Severe heart failure (New York Heart Association Class IV) or severe, uncontrolled cardiac disease
Positive test for HIV, hepatitis B or C, or symptoms or signs of active tuberculosis in a patient with a positive Quantiferon test.
Negative test for varicella zoster
Lymphopenia grade 2 (0.5 to 0.8 × 10^9/L) or higher grades of lymphopenia. In case of switching from fingolimod, siponimod or ozanimod lymphopenia is accepted at screening visit. Patients switching from dimethylfumarate who have persistent lymphopenia 5 to 6 weeks after stopping dimethylfumarate can be included if lymphopenia is grade 2 or lower, and treating phycisian judge CD20-depleting therapy safe.
Neutropenia grade 2 (1.0 to 1.5 × 10^9/L) or higher grades
Thrombocytopenia grade 2 (50 to 75 × 10^9/L) or higher grades
Previous treatment with alemtuzumab or hematopoietic stem-cell transplantation
Previous treatment with cladribine, CD20-depleting antibodies, daclizumab or other immune suppressive treatment which is judged to still exert immune suppressive effect by treating physician
Methylprednisolone treatment within 1 month of baseline visit
Findings on the screening MRI judged to preclude participation by the treating physician
Other diseases judged to be relevant by the treating physician
Contraindication to MRI
Known allergy or hypersensitivity to rituximab or ocrelizumab

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

600 participants in 2 patient groups

Rituximab

Experimental group

Description:

Intravenous biosimilar rituximab (Ruxience®, Rixathon® or other biosimilar rituximab) 1000 mg given every 6th month (first 2 infusions 1000mg/1000 mg given 2 weeks apart).

Treatment:

Drug: Paracetamol

Drug: Methylprednisolone

Drug: Fexofenadine

Drug: Rituximab

Ocrelizumab

Active Comparator group

Description:

Intravenous ocrelizumab (Ocrevus®) 600 mg every 6th month (first 2 infusions 300 mg/300 mg given 2 weeks apart).

Treatment:

Drug: Paracetamol

Drug: Methylprednisolone