Non-invasive Assessment of Intraocular Pressure in MPS by Use of the Ocular Response Analyzer. (MPSORA)

Johannes Gutenberg University (JGU)

Status: Unknown

Conditions: Mucopolysaccharidosis; Fabry Disease

Study type: Observational

Funder types: Other

Identifiers

NCT01695161

MZ-MPS-2012-01

Details and patient eligibility

About

The aim of the present study is to compare intraocular pressure (IOP) values assessed with Ocular Response Analyzer to the classical gold standard of IOP measurement, to Goldmann applanation tonometry by mucopolysacchyridosis-, Fabry-patients and healthy controls. We want to investigate biomechanical characteristics of the cornea and their influence on the IOP-measurements.

Enrollment: 75 estimated patients

Sex: All

Ages: 12+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• MPS I, II, IV, VI patients with at least grade 3 of corneal clouding (Couprie et al.)
• Fabry patients with cornea verticillata > grade 1
• Age ≥ 12 years
• Patient is able to comply with the study procedure
• Patient has consented to be in the trial
• Ability to fixate a target

Exclusion criteria

• History of corneal transplantation or refractive surgery
• Corneal pathologies other than MPS-associated corneal opacity
• Corneal, conjunctival or intraocular inflammation

Trial design

75 participants in 3 patient groups

mucopolysaccharidosis

Description:

mucopolysaccharidosis

Fabry disease

Description:

Fabry disease

healthy controls

Description:

healthy controls