Non Invasive Cancer Test (NICT): a Proof of Principle Study. (NICT-NIPT-CA)

Maastricht University Medical Centre (MUMC)

Status: Enrolling

Conditions: Neoplasmata

Treatments: Genetic: Isolation of tumor DNA

Study type: Observational

Funder types: Other

Identifiers

NCT03019471

NL55080.068.15

Details and patient eligibility

About

The investigators aim to collect tumor DNA out of blood of cancer patients. If this is successful this could lead to the development of a cancer test in blood in the future, which is less invasive than current diagnostic methods.

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients with newly diagnosed local or metastatic breast cancer, colorectal cancer, non-small cell lung cancer and anaplastic glioblastoma, before start of radiation therapy, chemoradiation or chemotherapy.
2. Patients age > 18 years, willing and able to comply with the protocol as judged by the investigator with a signed informed consent

Exclusion criteria

1. Patients with a history of malignant disease other than the disease under study, with an exception for adequately treated squamous cell carcinoma of the skin, basal cell carcinoma of the skin and in situ cervix carcinoma.
2. Pregnancy

Trial design

40 participants in 4 patient groups

Lung cancer

Description:

Isolate Tumor DNA from the patients blood.

Treatment:

Genetic: Isolation of tumor DNA

Breast cancer

Description:

Isolate Tumor DNA from the patients blood.

Treatment:

Genetic: Isolation of tumor DNA

Colorectal cancer

Description:

Isolate Tumor DNA from the patients blood.

Treatment:

Genetic: Isolation of tumor DNA

Glioma

Description:

Isolate Tumor DNA from the patients blood.

Treatment:

Genetic: Isolation of tumor DNA