Non-invasive Characterisation of Oral Carcinomas in Patients With Fanconi Anaemia (Fanc-Oral)

Institut Jean-Godinot

Status: Begins enrollment in 1 month

Conditions: Fanconi Anaemia

Treatments: Other: Oral brushing

Study type: Interventional

Funder types: Other

Identifiers

NCT07242261

2025_RIPH_04_Fanc-Oral

Details and patient eligibility

About

Patients with Fanconi anaemia have an increased risk of developing squamous cell carcinoma of the head and neck. In addition, their genetic vulnerability limits the use of genotoxic treatments such as radiotherapy and chemotherapy, due to increased exposure to severe toxicities.

Less invasive diagnostic techniques, such as brush biopsies, which rely on cytological and ploidy analysis, offer the possibility of more systematic, comprehensive and less painful oral mapping, thereby facilitating earlier diagnosis.

Full description

The aim of the study is to investigate the capabilities of oral brushing for the characterisation of oral lesions in patients with Fanconi anaemia.

Enrollment: 115 estimated patients

Sex: All

Ages: 15+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• have Fanconi anaemia
• are aged 15 years or older
• have at least one oral lesion with or without warning signs
• who agree to participate in the study

Exclusion criteria

• pregnant and breastfeeding women
• protected by law (guardianship, curatorship, judicial protection)
• refusing to participate in the study

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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115 participants in 1 patient group

Patients with Fanconi anaemia

Experimental group

Treatment:

Other: Oral brushing