Non-invasive Characterization of Systemic Microvascular Reactivity by Near-infrared Diffuse Optical Spectroscopy in COVID-19 Patients (HEMOCOVID19)

Corporacion Parc Tauli

Status

Enrolling

Conditions

Endothelial Function

COVID-19

Treatments

Device: Vascular occlusion test

Study type

Observational

Funder types

Other

Identifiers

NCT04689477

2020/579

Details and patient eligibility

About

The purpose of this study is to characterize microvascular reactivity on the forearm muscle using non-invasive near-infrared spectroscopy in critically ill COVID-19 patients, and to correlate its alterations with 28-day mortality in ICU COVID-19 patients.

Full description

After giving consent to participate in the study, the subjects included in the study will undergo a 15-minute measurement of tissue oxygen saturation (StO2) measured non-invasively on the forearm by means of near-infrared spectroscopy (NIRS). Once a baseline stable StO2 value is obtained, a provocative test, consisting of a transient vascular occlusion, will be performed. The test will allow the obtention of a local metabolic rate, and a StO2 recovery rate after the ischemic stimulus. This StO2 recovery rate will be considered as a reflection of the endothelial health of the patient.

Patients will be studied as soon as possible after admission to the ICU, and followed-up until ICU discharge or death.

Enrollment

612 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Recent diagnosis of SARS-CoV2 infection
Arterial hypoxemia and bilateral alveolar infiltrates, not explained by cardiac dysfunction or fluid overload.

Exclusion criteria

Severe peripheral vasculopathy
Raynaud's syndrome
Skin lesions or trauma in upper limbs interfering the placement of NIRS probe and/or the occlusion tourniquet
Deep venous thrombosis in the upper limbs