Non-Invasive Diagnostic and Functional Evaluation of Cardiac Involvement in Patients With Systemic Sclerosis

Medical University of Warsaw

Status: Unknown

Conditions: Systemic Sclerosis

Study type: Observational

Funder types: Other

Identifiers

NCT00453752

KB/66/2006

Details and patient eligibility

About

The aim of this study was to assess serum N-terminal proBNP (NT-proBNP) in systemic sclerosis patients and to establish whether it reflects the severity of RV overload.

Full description

Elevated serum brain natriuretic peptide (BNP) levels released from myocytes of ventricles upon stretch have been found in patients with isolated right ventricular (RV) pressure overload. However, limited data suggest that serum BNP may be elevated in patients with systemic sclerosis (SSc), especially with RV dysfunction. The aim of this study was to assess serum N-terminal proBNP (NT-proBNP) in SSc patients and to establish whether it reflects the severity of RV overload.

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of systemic sclerosis

Exclusion criteria

• Cardiovascular disorders other than pulmonary hypertension
• Significant pulmonary function abnormalities
• Impaired renal function