Non-Invasive Evaluation of Fibrosis and Steatosis in Chronic Hepatopathy

Tischendorf, Jens, M.D.

Status: Unknown

Conditions: Steatohepatitis; Chronic Liver Disease; Fibrosis

Study type: Observational

Identifiers

NCT01246388

LU-TI-01

Details and patient eligibility

About

The purpose of this study is to evaluate non-invasive parameters for staging and grading of chronic hepatopathy in comparison to liver biopsy.

Full description

For diagnosis, staging and grading of chronic liver disease, liver biopsy is the gold standard to date. Unfortunately, being an invasive diagnostic method, liver biopsy has a significant morbidity. Furthermore, due to the small sample size, sampling error (over- or underestimating severity of liver disease) is a serious problem in diagnostic of chronic liver disease.

The objective of this study is to evaluate non-invasive diagnostic methods (MRI, elastography, ultrasound and serum parameters) in comparison to the gold standard to establish criteria for diagnostic in liver disease and reduce the necessary amount of liver biopsies in the future and allow regular follow up.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Chronic hepatopathy and necessity of liver biopsy

Exclusion criteria

• metal implants preventing MRI

Trial design

50 participants in 1 patient group

Chronic Liver Disease